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KMID : 0381920000300040389
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Korean Journal of Microscopy
2000 Volume.30 No. 4 p.389 ~ p.401
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Effects of Squalene in Mouse Kidney with Contaminated Mercury
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Kim Jong-Se
Lee Kyung-Hee
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Abstract
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The mouse for identifying the histological changes of kidney were also divided into the two groups; treated with only $HgCl_2$ (4 mg/kg), the group treated with $HgCl_2$ and squalene (200 mg/kg). The $HgCl_2$ treated only one time at first day. The squalene treated two times a day (12 hours interval) for every day. Each groups were divided into the five groups; 6, 12, 24, 48 and 72 hours after treated $HgCl_2$ and squalene. Historical changes of the kidneys were investigated by electron microscope. The group with only $HgCl_2$ showed that the nuclear membrane was shrinked, the inner membrane (cristae) of the mitochondria were destructed, and ribosomes on the rough endoplasmic reticulum were lost. The group treated with $HgCl_2$ and Squalene showed that the nuclear membrane was more rounded, the cristae of the mitochondria were almost normal shape, and more ribosomes on the rough endoplasmic reticulum were attached. Therefore , we concluded that squalene has significantly protective effects in kidney to harmful $HgCl_2$.
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KEYWORD
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$HgCl_2$, Historical changes, Kidney, Squalene
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